Profile

Picture of Johan Lindqvist

Johan Lindqvist

Associate Scientific Investigator, Cellular and Molecular Medicine

Cellular & Molecular Medicine

Collaboration(1)

Hendrikus Granzier

Grants(2)

Effect of Myostatin Inhibition on Muscle Size and Muscle Function in a Novel Mouse Model of Typical Nemaline Myopathy
2020·$0 / $104.5K·
External
Co-Investigator (COI)
muscle development, nemaline myopathy, myostatin inhibition, muscle function, mouse model
Modulating Myosin to Improve Muscle Strength in Nebulin-Based Nemaline Myopathy
2017·$116.8K·
External
Principal Investigator (PI)
muscle strength, myosin regulation, nemaline myopathy, muscle disorders, protein modulation

Publications(13)

Recent

The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size

2021

nebulin, z-repeats, super-repeats, vertebrates, animal size

Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism.

2020

myopathy, nebulin mutations, myofilament structural changes, pathomechanism, compound heterozygous

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy.

2019

muscle disorders, cytoskeletal organization, nuclear defects, contractility impairment, myopathy

Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy.

2019

cardiomyopathy, muscle contraction, nebulin, myopathy, drug therapy

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy NEM3)

2018

muscle weakness, sarcomere contractility, nemaline myopathy, acta1-related, dysfunctional

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

2018

respiratory muscles, mechanical ventilation, diaphragm atrophy, positive end-expiratory pressure, ventilator-induced injury

Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy.

2018

skeletal muscle, titin protein, passive stiffness, molecular spring, longitudinal hypertrophy

Titin-based mechanosensing modulates muscle hypertrophy

2018

mechanosensing, muscle hypertrophy, mechanotransduction, muscle biology, protein biomechanics

Modulating myosin restores muscle function in a mouse model of nemaline myopathy.

2016

muscle function, myosin modulation, nemaline myopathy, mouse model, muscle disease

Sexually dimorphic myofilament function in a mouse model of nemaline myopathy

2014

myofilament function, nemaline myopathy, mouse model, sexually dimorphic, muscle disorder