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Johan Lindqvist
Associate Scientific Investigator, Cellular and Molecular Medicine
Cellular & Molecular Medicine
Map Page
Research Area
nemaline myopathy,
mouse model,
myopathy,
muscle weakness,
respiratory muscles,
muscle contraction,
muscle function,
muscle disorders,
nebulin,
limb muscles
Grants
(2)
Effect of Myostatin Inhibition on Muscle Size and Muscle Function in a Novel Mouse Model of Typical Nemaline Myopathy
2020
·
$0 / $104.5K
·
External
Co-Investigator (COI)
muscle development,
nemaline myopathy,
myostatin inhibition,
muscle function,
mouse model
Modulating Myosin to Improve Muscle Strength in Nebulin-Based Nemaline Myopathy
2017
·
$116.8K
·
External
Principal Investigator (PI)
muscle strength,
myosin regulation,
nemaline myopathy,
muscle disorders,
protein modulation
Publications
(13)
Recent
The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size
2021
nebulin,
z-repeats,
super-repeats,
vertebrates,
animal size
Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism.
2020
myopathy,
nebulin mutations,
myofilament structural changes,
pathomechanism,
compound heterozygous
Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy.
2019
muscle disorders,
cytoskeletal organization,
nuclear defects,
contractility impairment,
myopathy
Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy.
2019
cardiomyopathy,
muscle contraction,
nebulin,
myopathy,
drug therapy
Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy NEM3)
2018
muscle weakness,
sarcomere contractility,
nemaline myopathy,
acta1-related,
dysfunctional
Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers
2018
respiratory muscles,
mechanical ventilation,
diaphragm atrophy,
positive end-expiratory pressure,
ventilator-induced injury
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy.
2018
skeletal muscle,
titin protein,
passive stiffness,
molecular spring,
longitudinal hypertrophy
Titin-based mechanosensing modulates muscle hypertrophy
2018
mechanosensing,
muscle hypertrophy,
mechanotransduction,
muscle biology,
protein biomechanics
Modulating myosin restores muscle function in a mouse model of nemaline myopathy.
2016
muscle function,
myosin modulation,
nemaline myopathy,
mouse model,
muscle disease
Sexually dimorphic myofilament function in a mouse model of nemaline myopathy
2014
myofilament function,
nemaline myopathy,
mouse model,
sexually dimorphic,
muscle disorder
Collaborations
(1)
Hendrikus Granzier
Mutual work: 1 Proposal﹒1 Grant﹒1 Supervisor
Collaboration Details
$116.8K / $221.3K Funding
10+ Publications
