Profile

Pascale Charest

Associate Professor, Cancer Biology - GIDP | Associate Professor, BIO5 Institute | Associate Professor, Chemistry and Biochemistry-Sci | Member of the Graduate Faculty | Associate Professor

Molecular and Cellular Biology

Full Page

Overview

Research

Collaboration(19)

Page 1 of 4

Grants(6)

The Role of Receptor Dynamics in Eukaryotic Chemotaxis
Active·2024·$1.6M·
External
Principal Investigator (PI)
cell signaling, eukaryotic biology, biophysics, chemotaxis, cellular mechanisms
The Role and Regulation of mTORC2 in Cell Migration
Active·2019·$1.5M / $1.6M·
External
Principal Investigator (PI)
cell migration, mtorc2, cell regulation, cell biology, undergraduate research
The Role and Regulation of mTORC2 in Cell Migration-Undergrad
Active·2019·$81.1K·
External
Principal Investigator (PI)
cell migration, mtorc2, cell regulation, cell biology, undergraduate research
The role and regulation of mTORC2 in cell migration-undergrad
Active·2019·$7.4K·
External
Principal Investigator (PI)
cell migration, mtorc2, cell regulation, cell biology, undergraduate research
Signaling Mechanisms Underlying the Directed Motility of Eukaryotic Cells
2015·$791.9K / $791.9K·
External
Principal Investigator (PI)
cell motility, signal transduction, cell biology, cytoskeleton dynamics, cell signaling

Page 1 of 2

Publications(25)

Recent

Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion

2022

cancer, cell biology, signal transduction, breast cancer, tumor metastasis

Proximity protein labeling in Dictyostelium with engineered ascorbic acid peroxidase 2.

2022

proximity labeling, protein engineering, cell biology, enzyme engineering, biochemistry

Ras, PI3K and mTORC2 three's a crowd?

2020

cell signaling, cancer biology, molecular biology, signal transduction, oncology

Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors

2019

caffeine, pi3k, mtorc2, dictyostelium, camp signaling

The cAMP-induced G protein subunits dissociation monitored in live Dictyostelium cells by BRET reveals two activation rates, a positive effect of caffeine and potential role of microtubules

2018

cell signaling, g protein, cellular imaging, caffeine, microtubules

Protein Kinase A spatiotemporally controls chemoattractant signaling pathways and is critical for gradient sensing in Dictyostelium

2017

protein kinase a, chemoattractant signaling, gradient sensing, dictyostelium, spatiotemporal control

The small GTPases Ras and Rap1 bind to and control TORC2 activity

2016

gtpases, torc2, ras, rap1, cell signaling

Studying chemoattractant signal transduction dynamics in Dictyostelium using BRET

2016

cell signaling, chemotaxis, signal transduction, bioluminescence, dictyostelium

Degradation of activated K-ras orthologue via K-ras-specific lysine residues is required for cytokinesis

2014

cancer, cell biology, protein degradation, cell cycle, k-ras

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

2013

cell motility, signal transduction, protein function, cellular signaling, biological regulation

People

Profile

Pascale Charest

Collaboration(19)

Sanlyn Buxner

Megha Padi

Joyce Schroeder

Robin Polt

Paul Langlais