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Picture of Gregory Thatcher

Gregory Thatcher

Member of the Graduate Faculty | Professor, Chemistry and Biochemistry | Professor, Pharmacology and Toxicology | Professor, Neuroscience - GIDP | Endowed Chair, R Ken and Donna Coit - Drug Discovery

Pharmacology and Toxicology

Collaboration(36)

Todd Vanderah
Megha Padi
Fayez Ghishan
Scott Sherman
Nathan Cherrington

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Grants(14)

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Publications(12)

Recent

Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity.

2022

drug development, antiviral therapy, enzyme inhibitors, sars-cov-2, protease inhibitors

Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer

2021

breast cancer, estrogen mimic, endocrine-resistant, unfolded protein response, apoptosis

Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs

2021

drug development, pharmacology, biochemistry, medicine, cell biology

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

2021

filovirus entry, small molecules, mechanisms, inhibitors, viral entry

Extending the Calpain–Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma

2021

neurovasculature, calpain, cathepsin, neurotrauma, brain endothelial cells

Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

2021

antiviral therapy, sars-cov-2, plpro inhibitors, binding cooperativity, design

MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

2021

pancreatic cancer, cell signaling, tumorigenesis, kinase activation, cancer research

Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

2021

metabolomics, abca1, obesity, therapeutic development, inducer

Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human

2021

neuroinflammation, synaptic proteins, behavior, candesartan treatment, female mice

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

2021

sars-cov-2, plpro inhibitors, viral replication, monkey cell cultures, human cell cultures