ABCA1, also known as ATP-binding cassette sub-family A member 1, is a protein that plays a crucial role in cellular cholesterol and lipid transport. Research in the area of ABCA1 primarily focuses on understanding its function in reverse cholesterol transport, which is the process by which excess cholesterol is removed from peripheral tissues and transported back to the liver for excretion. ABCA1 is known to facilitate the efflux of cholesterol and phospholipids from cells to lipid-poor apolipoproteins, which then form high-density lipoprotein (HDL) particles. Dysregulation of ABCA1 function has been linked to various metabolic disorders, including atherosclerosis and Tangier disease. Researchers are exploring potential therapeutic strategies to target ABCA1 in order to improve lipid metabolism and reduce the risk of cardiovascular disease.