Tally Largent-Milnes

Associate Professor, BIO5 Institute | Member of the Graduate Faculty | Associate Professor, Pharmacology

About

The opioid and chronic pain epidemics go hand in hand; my lab investigates the intersection between the physiology of chronic pain states, analgesic pharmacology, and overcoming the gatekeeper of CNS pharmacology- the blood brain barrier.

Diversity in Research Education in Aging Medicine and Science
Active·2024·$0 / $288.3K·
External
diversity, education research, aging, medicine, science
Neuroscience Diversity to Elevate Education and Research Development
Active·2024·$0 / $269.2K·
External
neuroscience, diversity, education, research development
Targeting the Endocannabinoid System for Headache Intervention
Active·2023·$996.6K / $1.2M·
External
Principal Investigator (PI)
cannabinoids, headaches, neuroscience, pain management, pharmacology
Physiological Function of Persistent Inward Currents in Motor Neurons
Active·2023·$40.8K / $408.4K·
External
Co-Investigator (COI)
neuroscience, electrophysiology, neuromuscular control, ion channels, motor control
Discovery and Validation of a Novel Orphan GPCR as a Target for Therapeutic Intervention in Neuropathic Pain
Active·2023·$35.5K / $71K·
External
Co-Investigator (COI)
g-protein-coupled receptor, neuropathic pain, therapeutic intervention, discovery, validation

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Recent

ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache

2023

neuroscience, pain management, enzyme regulation, cannabinoid signaling, headache research

Morphine-induced osteolysis and hypersensitivity is mediated through toll-like receptor-4 in a murine model of metastatic breast cancer

2023

pain, cancer, inflammation, bone, immunology

Depletion of Endothelial-Derived 2-AG Reduces Blood-Endothelial Barrier Integrity via Alteration of VE-Cadherin and the Phospho-Proteome

2023

endothelial function, blood barrier, 2-ag depletion, ve-cadherin, phospho-proteome

The endocannabinoid system and breathing

2023

neuroscience, respiratory physiology, pharmacology, endocannabinoid system, medical physiology

PNA6, a Lactosyl Analogue of Angiotensin-1-7) Reverses Pain Induced in Murine Models of Inflammation, Chemotherapy-Induced Peripheral Neuropathy, and Metastatic Bone Disease

2023

pain relief, inflammation, chemotherapy, peripheral neuropathy, metastatic bone disease

Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients

2023

migraine, hormones, transgender health, molecular mechanisms, translational medicine

Identification of a Dynamic Mfn2 Phosphoregulatory Switch in Mitochondrial Fusion

2023

mitochondrial dynamics, protein phosphorylation, cellular signaling, mitochondrial fusion, cellular metabolism

Targeting 5-HT receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model

2022

neuropathic pain, 5-ht receptors, kv7 channels, pfc, animal model

Green Light Exposure Elicits Anti-inflammation, Endogenous Opioid Release and Dampens Synaptic Potentiation to Relieve Post-surgical Pain

2022

pain management, light therapy, inflammation, opioid release, synaptic potentiation

Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport

2022

mitochondrial dynamics, gtpases, intracellular transport, cellular signaling, membrane dynamics

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Pharmacology Researchers Seek Solutions to Opioid Epidemic
2018

Drugs of Abuse
Pain/Neuropharmacology
Pain
Neuropharmacolgy
Introduction to Pharmacology

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Using the Serum Phosphoproteome of Migraine Patients as a Theragnostic
2022·Technology
ANG-(1-7) Derivative Oligopeptides for the Treatment of Pain
2021·Patent
Targeting 2AG Degradation for Headache
2019·Technology
Targeted Therapy for Itch
2019·Technology
ANG-(1-7) Derivative Oligopeptides for the Treatment of Pain and Other Indications
2019·Patent

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Tally Largent-Milnes

About

Research Area

Grants(18)

Diversity in Research Education in Aging Medicine and Science

Neuroscience Diversity to Elevate Education and Research Development

Targeting the Endocannabinoid System for Headache Intervention

Physiological Function of Persistent Inward Currents in Motor Neurons

Discovery and Validation of a Novel Orphan GPCR as a Target for Therapeutic Intervention in Neuropathic Pain

Publications(85)

ABHD6 and MAGL control 2-AG levels in the PAG and allodynia in a CSD-induced periorbital model of headache

Morphine-induced osteolysis and hypersensitivity is mediated through toll-like receptor-4 in a murine model of metastatic breast cancer

Depletion of Endothelial-Derived 2-AG Reduces Blood-Endothelial Barrier Integrity via Alteration of VE-Cadherin and the Phospho-Proteome

The endocannabinoid system and breathing

PNA6, a Lactosyl Analogue of Angiotensin-1-7) Reverses Pain Induced in Murine Models of Inflammation, Chemotherapy-Induced Peripheral Neuropathy, and Metastatic Bone Disease

Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients

Identification of a Dynamic Mfn2 Phosphoregulatory Switch in Mitochondrial Fusion

Targeting 5-HT receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model

Green Light Exposure Elicits Anti-inflammation, Endogenous Opioid Release and Dampens Synaptic Potentiation to Relieve Post-surgical Pain

Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport

Collaborations(58)

Timian Godfrey

Helena Morrison

Janko Nikolich

Todd Vanderah

Bellal Joseph

News(1)

Pharmacology Researchers Seek Solutions to Opioid Epidemic

Courses(6)

Drugs of Abuse

Pain/Neuropharmacology

Pain

Neuropharmacolgy

Introduction to Pharmacology

Techs/Patents(6)

Using the Serum Phosphoproteome of Migraine Patients as a Theragnostic

ANG-(1-7) Derivative Oligopeptides for the Treatment of Pain

Targeting 2AG Degradation for Headache

Targeted Therapy for Itch

ANG-(1-7) Derivative Oligopeptides for the Treatment of Pain and Other Indications