Steven Schwartz

Professor, BIO5 Institute | Member of the Graduate Faculty | Regents Professor | Professor, Chemistry and Biochemistry-Sci | Professor, Applied Mathematics - GIDP

Chemistry & Biochemistry - Sci

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Research Area

enzyme kinetics, protein dynamics, biochemistry, enzyme catalysis, protein structure, molecular dynamics, molecular biology, catalysis, enzyme mechanism, isotope effects, structural biology, enzyme design, biophysics, evolution, biophysical chemistry, enzyme engineering, directed evolution, cardiomyopathy, genetic cardiomyopathy

Blunting of the Myofilament Beta-Adrenergic Response in HCM: Structural-Dynamic Mechanisms
Active·2023·$0 / $85K·
External
Key Personnel (KP)
cardiomyopathy, myofilament, beta-adrenergic, structural dynamics, biomedical research
Protein Dynamics from Femtoseconds to Milliseconds as Crafted by Natural and Laboratory Evolution: Towards Enzyme Design
Active·2022·$1.1M·
External
Principal Investigator (PI)
protein dynamics, enzyme design, evolution, enzyme engineering, biochemistry
Evolving Quantum Mechanical Tunnelling in Enzymes
Active·2022·$647.1K·
External
Principal Investigator (PI)
enzyme catalysis, quantum biology, enzyme kinetics, quantum mechanics, biochemistry
Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies
Active·2021·$849K / $1.7M·
External
Key Personnel (KP)
cardiomyopathies, remodeling, integrative approach, thin filament, divergent
The Interaction of Myosin and The Thin Filament: How Mutations Cause Allosteric Dysfunction and Their Connection to Genetic Cardiomyopathy
Active·2020·$1.5M / $3M·
External
Multiple Principal Investigator (MPI)
genetic cardiomyopathy, myosin, allosteric dysfunction, thin filament, mutations

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Recent

Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases

2021

enzyme kinetics, isotope effects, nucleosidases, biochemistry, catalysis

Investigation of the Recovery Stroke and ATP Hydrolysis and Changes Caused Due to the Cardiomyopathic Point Mutations in Human Cardiac β Myosin

2021

cardiomyopathy, atp hydrolysis, stroke, point mutations, human cardiac β myosin

A Proposed Mechanism for the Initial Myosin Binding Event on the Cardiac Thin Filament: A Metadynamics Study

2021

cardiac muscle, molecular dynamics, myosin binding, muscle contraction, biophysical interactions

Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament

2021

genetic variants, cardiac health, biophysical modeling, pathogenicity, computational analysis

Multiple Reaction Pathways in the Morphinone Reductase-Catalyzed Hydride Transfer Reaction

2020

enzyme catalysis, organic chemistry, reaction mechanism, biocatalysis, enzyme kinetics

Directed Evolution's Influence on Rapid Density Fluctuations Illustrates How Protein Dynamics Can Become Coupled to Chemistry

2020

directed evolution, protein dynamics, chemistry, rapid density fluctuations, influence

A Classical Molecular Dynamics Simulation Study of Interfacial and Bulk Solution Aggregation Properties of Dirhamnolipids

2020

molecular dynamics, interfacial aggregation, solution properties, bulk solution, dirhamnolipids

Mechanochemical Function of Myosin II: Investigation into the Recovery Stroke and ATP Hydrolysis

2020

biomechanics, molecular biology, biochemistry, muscle physiology, enzyme kinetics

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

2020

cardiomyopathy, cardiac, twitch, modulation, murine

Role of Protein Motions in Catalysis by Formate Dehydrogenase

2020

enzyme catalysis, protein dynamics, biochemistry, enzyme mechanism, protein function

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Physical Chemistry
General Chemistry Lecture II: Quantitative Approach
Majors General Chemistry II
Statistical Thermodynamics
General Chemistry Lecture I: Quantitative

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Steven Schwartz

Research Area

Grants(20)

Blunting of the Myofilament Beta-Adrenergic Response in HCM: Structural-Dynamic Mechanisms

Protein Dynamics from Femtoseconds to Milliseconds as Crafted by Natural and Laboratory Evolution: Towards Enzyme Design

Evolving Quantum Mechanical Tunnelling in Enzymes

Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies

The Interaction of Myosin and The Thin Filament: How Mutations Cause Allosteric Dysfunction and Their Connection to Genetic Cardiomyopathy

Publications(124)

Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases

Investigation of the Recovery Stroke and ATP Hydrolysis and Changes Caused Due to the Cardiomyopathic Point Mutations in Human Cardiac β Myosin

A Proposed Mechanism for the Initial Myosin Binding Event on the Cardiac Thin Filament: A Metadynamics Study

Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament

Multiple Reaction Pathways in the Morphinone Reductase-Catalyzed Hydride Transfer Reaction

Directed Evolution's Influence on Rapid Density Fluctuations Illustrates How Protein Dynamics Can Become Coupled to Chemistry

A Classical Molecular Dynamics Simulation Study of Interfacial and Bulk Solution Aggregation Properties of Dirhamnolipids

Mechanochemical Function of Myosin II: Investigation into the Recovery Stroke and ATP Hydrolysis

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts

Role of Protein Motions in Catalysis by Formate Dehydrogenase

Collaborations(11)

Walter Klimecki

Robin Polt

Raina Maier

Hendrikus Granzier

Jeanne Pemberton

News(2)

Five UA Faculty Members Named Regents' Professors

Professor Links Gene Mutations With Heart Disease Precursors

Courses(7)

Physical Chemistry

General Chemistry Lecture II: Quantitative Approach

Majors General Chemistry II

Statistical Thermodynamics

General Chemistry Lecture I: Quantitative