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Shirin Doroudgar
Assistant Professor | Member of the Graduate Faculty
College of Medicine - Phoenix
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Research Area
heart,
gene expression,
cardiac hypertrophy,
endoplasmic reticulum,
atf6,
er stress,
cardiac remodeling,
stress response,
mtorc1,
heart failure,
cardiovascular disease,
cardiac,
protein misfolding
Grants
(2)
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Publications
(47)
Recent
ATF6 protects against protein misfolding during cardiac hypertrophy
2024
protein misfolding,
cardiac hypertrophy,
atf6,
cardiovascular disease,
cellular stress response
Proteostasis in cardiac health and disease
2024
proteostasis,
cardiac health,
disease,
protein homeostasis
Development of a protein synthesis network at the sarco/endoplasmic reticulum in adult cardiac myocytes
2024
protein synthesis,
cardiac myocytes,
endoplasmic reticulum,
network development
Signaling and Stress Response: mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes
2023
cell death,
stress response,
mtorc1 inhibition,
unfolded protein response,
er stress
Resolving Proteotoxicity: Genetic Examination of Proteasome Activation by PKA In Vivo
2023
proteasome activation,
genetic examination,
proteotoxicity,
pka,
in vivo
Krüppel-like factor 15 expression dynamics with CRISPR-based gene activation controls cardiomyocyte remodeling in the failing heart
2022
gene expression,
cardiomyocyte remodeling,
crispr-based gene activation,
heart failure,
krüppel-like factor 15
VARS2 depletion leads to activation of the integrated stress response and disruptions in mitochondrial fatty acid oxidation
2022
mitochondrial function,
cellular stress response,
fatty acid metabolism,
genetic depletion,
metabolic pathways
Transcriptional Effects of Candidate COVID-19 Treatments on Cardiac Myocytes
2022
covid-19,
cardiac,
transcriptional,
treatment,
myocytes
IRE1/XBP1 and endoplasmic reticulum signaling—from basic to translational research for cardiovascular disease
2022
endoplasmic reticulum,
cardiovascular disease,
ire1/xbp1,
translational research,
signaling
Abstract MP217: Nuclease-deficient Cas9 Transcription Factors Restore Krueppel-like Factor 15 Expression In Stressed Mouse And Human Cardiomyocytes
2021
genome editing,
cardiomyocyte function,
transcription regulation,
stress response,
gene expression
Collaborations
(5)
Shenfeng Qiu
Mutual work: 2 Proposals
Collaboration Details
Tobias Jakobi
Mutual work: 2 Grants﹒8 Proposals
Collaboration Details
Chris Glembotski
Mutual work: 2 Grants﹒5 Proposals
Collaboration Details
Shanna Hamilton
Mutual work: 1 Proposal
Collaboration Details
Cecily Haskell
Mutual work: 2 Proposals﹒1 Supervisor﹒1 Grant
Collaboration Details
4+ Collaborators
$565.9K / $904.5K Funding
40+ Publications
