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Paulo Pires
Member of the Graduate Faculty | Assistant Professor, Physiology | Assistant Professor, Surgery
Physiology
Map Page
Research Area
alzheimer's disease,
hypertension,
neuroscience,
mouse model,
cerebral arterioles,
ion channels,
vascular biology,
endothelium,
cerebral artery,
endothelial function,
neurodegeneration,
brain injury,
cell signaling,
aging,
potassium channels,
inflammation,
endothelial dysfunction,
vascular health,
cardiovascular disease,
rats,
obesity,
smooth muscle cells,
smooth muscle,
vascular physiology,
cerebral blood flow,
neuroprotection,
trpa1 channels,
calcium signaling,
sex differences,
lymphatic system
Grants
(6)
Role of Endothelial K + Channels in Age-Related Dementia
Active
·
2022
·
$661.4K / $826.7K
·
External
Principal Investigator (PI)
neurodegeneration,
endothelial function,
potassium channels,
aging,
dementia
Investigating The Role Of Blood Flow In Heat Stress Hypophagia And Hypogalactia
Active
·
2022
·
$130K / $650K
·
External
Co-Investigator (COI)
heat stress,
hypophagia,
blood flow,
hypogalactia,
physiological response
Nonlipogenic ABCA1 inducers for ADRD
Active
·
2022
·
$93.3K / $373K
·
External
Co-Investigator (COI)
alzheimer's disease,
cholesterol metabolism,
drug discovery,
neurodegeneration,
lipid transport
Improving Glymphatic and Microvascular Function in Alzheimer's Disease
Active
·
2021
·
$149.8K
·
External
Principal Investigator (PI)
alzheimer's,
glymphatic function,
microvascular function,
brain health,
neurodegenerative diseases
Arizona Alzheimer's Consortium Match Projects
2022
·
$10.5K / $350K
·
External
Co-Investigator (COI)
alzheimer's,
consortium,
arizona,
match,
projects
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Publications
(95)
Recent
Sex-specific mechanisms of cerebral microvascular BK Ca dysfunction in a mouse model of Alzheimer's disease
2024
alzheimer's disease,
mouse model,
sex-specific mechanisms
Nitro-oxidation of BKCa mediates neuro- and micro-vascular dysfunction in female 5x-FAD mice
2024
oxidative stress,
neurovascular dysfunction,
alzheimer's disease,
potassium channels,
vascular physiology
Cervical lymphatic vessel dysfunction induced by amyloid-β and in the 5x-FAD mouse model of Alzheimer’s disease
2024
alzheimer's disease,
lymphatic system,
amyloid-β,
mouse model
The ebbs and tides of endothelial K+ currents that regulate blood flow
2024
endothelial function,
potassium channels,
blood flow regulation
TRP channels in cerebral vascular disorders
2024
trp channels,
neuroscience,
ion channels,
vascular biology
TRPV4 Channels Are Not Involved in Pressure-Induced Contraction of Mouse Superficial Lymphatic Vessels
2023
vascular physiology,
lymphatic system,
mechanotransduction,
ion channels,
biomechanics
PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia
2023
neurovascular,
blood-brain barrier,
mas receptor,
vascular cognitive impairment,
dementia
BKCa nitrosylation is associated with cerebral microvascular dysfunction in female 5x-FAD mice
2023
nitrosylation,
cerebral microvascular dysfunction,
5x-fad mice,
bkca channel,
female
Endothelial KIR2 channel dysfunction in aged cerebral parenchymal arterioles
2023
endothelial function,
aging,
cerebral arterioles,
ion channels,
vascular dysfunction
A novel therapeutic Ang 1-7) analogue improves neurovascular function in mice with vascular contributions to cognitive impairment and dementia
2023
neurovascular function,
cognitive impairment,
dementia,
therapeutic analogue,
vascular contributions
Collaborations
(28)
Marlys Witte
Mutual work: 1 Grant﹒6 Proposals﹒8 Publications
Collaboration Details
Lee Ryan
Mutual work: 1 Grant﹒2 Proposals
Collaboration Details
Russell Witte
Mutual work: 5 Proposals﹒4 Publications
Collaboration Details
John Konhilas
Mutual work: 2 Proposals﹒1 Publication
Collaboration Details
Theodore Trouard
Mutual work: 1 Grant﹒3 Proposals
Collaboration Details
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Courses
(3)
Human Physiology
Physiology for Biomedical Engineering
Cellular and Molecular Physiology
20+ Collaborators
$1.8M / $3.1M Funding
5+ Grants
90+ Publications
