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Jeffrey Lochhead
Assistant Research Professor, Pharmacology - (Research Series Track)
Pharmacology
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Research Area
blood-brain barrier,
ischemic stroke,
drug delivery,
intranasal administration,
neuroprotection,
neuroscience,
drug transport,
transporters,
pharmacology,
central nervous system
Grants
(3)
Increased CNS Opioid Exposure by an Acetaminophen-Induced Blood-Brain Barrier Mechanism
Active
·
2020
·
$280K / $2.8M
·
External
Co-Investigator (COI)
opioid exposure,
blood-brain barrier,
acetaminophen,
cns,
drug-induced mechanism
Targeting Blood-Brain Barrier Transporters to Treat Ischemic Stroke
Active
·
2020
·
$278.1K / $2.8M
·
External
Co-Investigator (COI)
ischemic stroke,
blood-brain barrier,
transporters,
treatment,
targeting
Intranasal Insulin as a Neuroprotectant during Hypoxia/Reoxygenation Stress
2018
·
$231K
·
External
Principal Investigator (PI)
neuroprotection,
hypoxia,
insulin,
reoxygenation,
stress
Publications
(42)
Recent
Abstract TP209: Role Of Endoglin In The Regulation Of Organic Anion Transporting Polypeptide 1a4 At The Blood-brain Barrier: Relevance To The Treatment Of Ischemic Stroke
2023
neuroscience,
ischemic stroke,
blood-brain barrier,
organic anion transport,
endoglin regulation
Oat(Organic Anion Transporting Polypeptide)Mediated Transport: A Mechanism for Atorvastatin Neuroprotection in Stroke
2023
drug transport,
neuroprotection,
stroke,
organic anion transporting polypeptide,
atorvastatin
Localization And Expression Of Transporters For Cationic Drugs At The Blood-brain Barrier: Relevance To The Pharmacotherapy Of Ischemic Stroke
2023
transporter localization,
cationic drugs,
blood-brain barrier,
pharmacotherapy,
ischemic stroke
Organic Anion Transporting Polypeptides: Endogenous Blood-brain Barrier Transporters That Are Required For Statins To Exert Neuroprotective Effects In Ischemic Stroke
2023
drug transporters,
ischemic stroke,
neuroprotective effects,
blood-brain barrier,
organic anion transporting polypeptides
Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors i.e. Statins)
2022
blood-brain barrier,
transporters,
signaling pathways,
brain disposition,
statins
Intranasal drug delivery to the brain
2022
drug delivery,
neuroscience,
brain,
intranasal,
pharmacology
Regulation of blood-brain barrier transporters by transforming growth factor-β/Activin Receptor-Like Kinase 1 Signaling: relevance to the brain disposition of 3-hydroxy-3 …
2022
blood-brain barrier,
transforming growth factor,
brain disposition,
transporters,
activin receptor-like kinase 1 signaling
β-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
2022
cell signaling,
β-spectrin,
vegf regulation,
stalk cells,
cell biology
High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats
2022
acetaminophen,
blood-brain barrier,
cns uptake,
codeine,
integrity
High Resolution Multiplex Confocal Imaging of the Neurovascular Unit in Health and Experimental Ischemic Stroke
2022
neuroimaging,
ischemic stroke,
neurovascular unit,
high-resolution imaging,
experimental research
Collaborations
(4)
Tally Largent-Milnes
Mutual work: 1 Proposal
Collaboration Details
Patrick Ronaldson
Mutual work: 2 Grants﹒12 Proposals﹒10 Publications
Collaboration Details
Thomas Davis
Mutual work: 2 Grants﹒9 Proposals﹒12 Publications
Collaboration Details
Sharon Hom
Mutual work: 1 Publication
Collaboration Details
Courses
(1)
Molecular Targets of Pharmacological Agents
$789.2K / $5.8M Funding
40+ Publications