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Picture of Ghassan Mouneimne

Ghassan Mouneimne

Member of the Graduate Faculty | Assistant Professor, Cancer Biology - GIDP | Associate Professor, Cellular and Molecular Medicine

Cellular & Molecular Medicine

Research Area

cancer, breast cancer, protein regulation, cell invasion, vascular biology, cell biology, metastasis, cell migration, tumor microenvironment, estrogen receptor, cellular signaling

Targeting Matrix Stiffness to Block Invasion Progression of ER+ Breast Cancer
Active·2023·$166.7K / $100K·
External
Principal Investigator (PI)
cancer, breast cancer, matrix stiffness, invasion, treatment
The Dynamic Angiogenic Network Underpinning Coronary Artery Disease
2021·$13.8K / $275K·
External
Co-Investigator (COI)
angiogenesis, coronary artery disease, vascular biology, network analysis, cardiovascular disease
Defining the Role of PIM Kinases in Hypoxia-Induced Invasion and Metastasis
2019·$89.1K / $891.4K·
External
Co-Investigator (COI)
cancer, cell biology, hypoxia, metastasis, kinases
Novel Mechanism of Breast Cancer Invasion Prevention by Estrogen Receptor
2016·$91.3K / $182.7K·
External
Principal Investigator (PI)
breast cancer, estrogen receptor, cancer invasion, mechanism, prevention
Novel Mechanism of Breast Cancer Invasion Prevention by Estrogen Receptor
2015·$1.7M / $1.9M·
External
Principal Investigator (PI)
breast cancer, estrogen receptor, cancer invasion, mechanism, prevention

Page 1 of 2

Recent

Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion

2023

cancer, cell biology, signal transduction, breast cancer, tumor metastasis

Optimized in vitro three-dimensional invasion assay for quantifying a wide range of cancer cell invasive behavior

2022

cancer cell invasion, in vitro assay, three-dimensional, optimized quantification, cancer research

βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling.

2022

cell biology, signal transduction, vascular biology, protein regulation, cytoskeleton

Abstract 2416: Ras-mediated activation of mTORC2 drives breast cancer cell migration and invasion

2022

cancer, cell migration, mtorc2, ras, invasion

Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

2022

protein interaction, actin dynamics, cell cytoskeleton, proline-rich motifs, cell motility

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

2021

protein interactions, actin dynamics, residue network, conformational specificity, dynamics

EDC3 Phosphorylation Regulates Growth and Invasion through controlling P-body Formation and Dynamics

2021

cellular signaling, cell growth, cancer metastasis, rna processing, cell invasion

Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning

2021

cancer, metastasis, tumor microenvironment, mechanotransduction, bone metastasis

EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in developing neurons

2021

neuronal development, actin regulation, cytoskeletal remodeling, cell filopodia, protein regulation

BIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling

2021

cell signaling, protein regulation, cell biology, cytoskeleton, vascular biology

H-H. Sherry Chow
Nirav Merchant
Rongguang Liang
Denise Roe
Andrew Rouse

Page 1 of 9

Despite COVID, UArizona Reports Strong Year for Innovation and Commercialization
2021
Study Finds Breast Cancer's Response to Tumor Stiffness May Predict Bone Metastasis
2021
'Evil' Proteins a Force for Good in Estrogen Receptor-Positive Breast Cancer
2018
Seeing Cancer Differently
2014

Cancer Biology
Principles of Cell Biology
Cell Biology of Disease
Fundamentals of Light Microscopy and Digital Imaging

Diagnostic Tool For Estrogen Receptor Positive Breast Cancer Patient Stratification
2018·Technology

40+ Collaborators

$2.1M / $3.6M Funding

40+ Publications