Dr Frank Porreca is Professor of Pharmacology and Anesthesiology at the University of Arizona in Tucson, Arizona. He also holds an appointment as a Senior Consultant in the Department of Collaborative Research at Mayo Clinic, Scottsdale, Arizona. He trained in Biomedical Engineering at Drexel University in Pharmacology at Temple University in Philadelphia. His dissertation work focused on drug-receptor theory and understanding of the actions of buprenorphine. He is the author of approximately 500 original, peer-reviewed articles addressing mechanisms of opioids and pain and has been recognized as a “Highly Cited” investigator by Pub Med and one of the 10 most cited pharmacologists in the world by the American Society of Pharmacology and Experimental Therapeutics. Dr Porreca has been honored by the International Association for the Study of Pain with the Ronald Melzack Award, by the American Pain Society with the Frederick W Kerr Award for Basic Research in Pain, by the British Pain Society with the Patrick Wall Award and by the Canadian Pain Society with the Mary Ellen Jeans Award. Dr Porreca is a former Editor in Chief of Life Sciences, Associate editor of Pain and Cephalalgia. He is a Fellow of the American Headache Society and of the American Association for the Advancement of Science.