Temozolomide is a chemotherapy drug that is commonly used in the treatment of certain types of brain tumors, including glioblastoma multiforme, an aggressive form of brain cancer. It works by damaging the DNA of cancer cells, leading to their death. Temozolomide is often used in combination with other treatments, such as radiation therapy, to improve outcomes for patients with brain tumors. Research on temozolomide focuses on understanding its effectiveness, side effects, and mechanisms of action, as well as developing new ways to enhance its therapeutic benefits and reduce its toxicities.