Sulfotransferases are enzymes that catalyze the transfer of a sulfate group from the donor molecule 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor molecule, typically a hydroxyl or amino group on another molecule. This process, known as sulfation, plays a crucial role in the metabolism and detoxification of various compounds in the body, including drugs, hormones, and xenobiotics. Sulfotransferases are found in various tissues and organs throughout the body and are involved in a wide range of physiological processes, such as hormone regulation, drug metabolism, and the biotransformation of dietary compounds. Dysregulation of sulfotransferase activity has been implicated in various diseases, including cancer, metabolic disorders, and neurological disorders. Thus, understanding the function and regulation of sulfotransferases is important for understanding their role in health and disease.