Notch3 is a gene that encodes a protein involved in cell signaling and development. It is part of the larger Notch signaling pathway, which plays a critical role in regulating cell differentiation, proliferation, and cell fate decisions. Mutations in the Notch3 gene have been linked to a variety of diseases, including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary condition that affects blood vessels in the brain. Research on Notch3 and its role in cellular processes is ongoing and has important implications for understanding disease mechanisms and potential therapeutic strategies.