Nociceptors are specialized sensory receptors that detect potentially harmful stimuli, such as intense pressure, temperature, or chemical irritants. They are primarily located in the skin, joints, and internal organs, and play a crucial role in the perception of pain. Activation of nociceptors triggers signaling pathways that ultimately result in the sensation of pain, as well as protective responses to avoid further injury. Research in this area focuses on understanding the molecular mechanisms underlying nociceptor function, as well as developing new treatments for pain conditions by targeting nociceptor signaling pathways.