Metalloproteinases are a family of enzymes that play a crucial role in the breakdown of extracellular matrix proteins, such as collagen, during physiological processes like tissue remodeling, wound healing, and cell migration. Dysregulation of metalloproteinases has been implicated in various pathological conditions, including cancer, cardiovascular diseases, and inflammation. Research in this area focuses on understanding the structure, function, and regulation of metalloproteinases, as well as developing inhibitors and therapeutic strategies to target these enzymes in disease prevention and treatment.