Grhl2 is a gene that encodes for a transcription factor called Grainyhead-like 2. This gene plays a critical role in regulating the development and maintenance of epithelial tissues in various organs, including the skin, lungs, and intestines. Research on Grhl2 has shown its importance in a variety of biological processes, such as cell proliferation, differentiation, and migration. Dysregulation of Grhl2 has been linked to several human diseases, including cancer, skin disorders, and developmental defects. Scientists continue to study the function of Grhl2 and its potential therapeutic applications in various diseases.