G-protein-coupled receptors (GPCRs) are a large and diverse family of cell surface receptors that play a crucial role in signal transduction. They are involved in a wide range of physiological processes, including sensory perception, neurotransmission, hormone response, and immune response. Research in the field of GPCRs aims to understand their structure, function, and signaling mechanisms, as well as to develop novel therapeutics targeting these receptors for a variety of diseases and conditions. GPCRs are one of the most important drug targets in pharmacology, with many commonly used medications acting on these receptors.