Chaperones are a group of molecules that assist in protein folding, unfolding, assembly, disassembly, and translocation across membranes. These molecules play a crucial role in maintaining the structural integrity and functional activity of proteins in cells. Chaperones help to prevent misfolding and aggregation of proteins, as well as facilitate the correct folding of newly synthesized proteins. They are also involved in the refolding of denatured proteins and the degradation of misfolded or damaged proteins. Chaperones are essential for protein homeostasis and are implicated in various cellular processes, including stress response, protein trafficking, and proteostasis. Research in the field of chaperones aims to understand their mechanisms of action, regulation, and dysfunction in various diseases, such as neurodegenerative disorders and cancer.