Alpha-synuclein is a protein that is abundant in the brain and plays a role in neurotransmission. It is primarily associated with Parkinson's disease, as it forms clumps called Lewy bodies in the brains of individuals with the condition. Research on alpha-synuclein focuses on understanding its function in healthy brain function, as well as how its misfolding and aggregation contribute to neurodegenerative diseases like Parkinson's. Scientists are also investigating potential therapeutic approaches to target alpha-synuclein and slow down the progression of Parkinson's disease.