AICAR, also known as 5-aminoimidazole-4-carboxamide ribonucleotide, is a synthetic compound that has been studied for its potential applications in the fields of exercise physiology, metabolism, and cell biology. AICAR is often used as an activator of AMP-activated protein kinase (AMPK), a key enzyme involved in energy regulation and metabolism in cells. Research on AICAR has shown that it can enhance glucose uptake and fatty acid oxidation in muscles, increase endurance and improve exercise performance in animal models. Additionally, AICAR has been investigated for its potential therapeutic benefits in treating various metabolic disorders and diseases such as diabetes, obesity, and cardiovascular diseases. Overall, research in the field of AICAR is focused on understanding its mechanisms of action, exploring its potential applications in improving metabolic health and exercise performance, and identifying its possible therapeutic uses in various diseases.