Profile

Noel Warfel

Associate Professor, Cellular and Molecular Medicine | Associate Professor, Cancer Biology - GIDP | Vice Chair, Cancer Biology - GIDP | Member of the Graduate Faculty

Cellular & Molecular Medicine

Full Page

Overview

Research

Collaboration(33)

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Grants(10)

University of Arizona Cancer Center - Cancer Center Support Grant
Active·2022·$0 / $12.6M·
External
Key Personnel (KP)
cancer research, medical oncology, grants, cancer treatment, supportive care
Development of Non-Catalytic Peptide Inhibitors of Focal Adhesion Kinase (FAK) for Use in Melanoma
Active·2022·$599.8K·
External
Principal Investigator (PI)
peptide inhibitors, focal adhesion kinase, melanoma, drug development, cancer therapy
PIM Kinases Alter Mitochondrial Dynamics and Response to Therapy in Lung Cancer
Active·2021·$225K·
External
Principal Investigator (PI)
lung cancer, mitochondrial dynamics, therapy, pim kinases, response
Centrosome Instability as a Mechanism to Promote Localized Prostate Cancer
Active·2019·$280.6K / $2.9M·
External
Co-Investigator (COI)
prostate cancer, cell biology, genomic instability, cancer biology, cell cycle
Centrosome instability as a mechanism to promote localized prostate cancer
Active·2019·$5.6K / $55.6K·
External
Co-Investigator (COI)
prostate cancer, cell biology, genomic instability, cancer biology, cell cycle

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Publications(59)

Recent

Abstract B026: PIM kinases regulates tumor associated macrophage survival and inflammatory signaling

2023

cancer, immunology, cell signaling, kinases, macrophages

PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer

2023

prostate cancer, lipid droplets, proliferation, survival, cell growth

Digital Image analysis using Video microscopy of human-derived prostate cancer vs normaprostate organoids to assess migratory behavior on extracellular matrix proteins.

2023

digital image analysis, video microscopy, prostate cancer, organoid research, extracellular matrix

PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer

2023

prostate cancer, chemoresistance, pim1 inhibition, targeted degradation, cancer treatment

Insulin-stimulated phosphorylation of CLASP2 by ERK regulates microtubule plus-end binding of CLASP2 and insulin-regulated microtubule stabilization

2023

insulin signaling, microtubule dynamics, erk pathway, protein phosphorylation, cellular transport

PIM kinases regulate actin dynamics and tumor cell invasion in hypoxia

2023

kinase regulation, actin dynamics, tumor cell invasion, hypoxia response, cancer biology

PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.

2023

cancer, cell biology, protein phosphorylation, tumor invasion, actin dynamics

Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28

2022

protein kinases, hypoxia, deubiquitinase, stabilization, cell signaling

GLUT3/SLC2A3 is an endogenous marker of hypoxia in prostate epithelial and prostate cancer cells.

2022

hypoxia, prostate cancer, glut3/slc2a3, marker, prostate epithelial

Optimized in vitro three-dimensional invasion assay for quantifying a wide range of cancer cell invasive behavior

2022

cancer cell invasion, in vitro assay, three-dimensional, optimized quantification, cancer research

People

Profile

Noel Warfel

Collaboration(33)

Nirav Merchant

Melissa Herbst-Kralovetz

Denise Roe

Rongguang Liang

Benjamin Lee

Grants(10)

University of Arizona Cancer Center - Cancer Center Support Grant

Development of Non-Catalytic Peptide Inhibitors of Focal Adhesion Kinase (FAK) for Use in Melanoma

PIM Kinases Alter Mitochondrial Dynamics and Response to Therapy in Lung Cancer

Centrosome Instability as a Mechanism to Promote Localized Prostate Cancer

Centrosome instability as a mechanism to promote localized prostate cancer

Publications(59)

Abstract B026: PIM kinases regulates tumor associated macrophage survival and inflammatory signaling

PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer

Digital Image analysis using Video microscopy of human-derived prostate cancer vs normaprostate organoids to assess migratory behavior on extracellular matrix proteins.

PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer

Insulin-stimulated phosphorylation of CLASP2 by ERK regulates microtubule plus-end binding of CLASP2 and insulin-regulated microtubule stabilization

PIM kinases regulate actin dynamics and tumor cell invasion in hypoxia

PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.

Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28

GLUT3/SLC2A3 is an endogenous marker of hypoxia in prostate epithelial and prostate cancer cells.

Optimized in vitro three-dimensional invasion assay for quantifying a wide range of cancer cell invasive behavior