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Picture of Thomas Tomasiak

Thomas Tomasiak

Assistant Professor, Chemistry and Biochemistry | Assistant Professor, BIO5 Institute | Member of the Graduate Faculty

Chemistry & Biochemistry - Sci

Collaboration(15)

Nathan Cherrington
Wei Wang
Qing-Yu Zhang
Yin Chen
Gregory Thatcher

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Grants(6)

Evolution-guided Analysis of Extracellular and Intracellular Mechanisms Driving T Cell Activation
Active·2024·$34.1K / $682.4K·
External
Co-Investigator (COI)
evolution, t cell activation, intracellular mechanisms, extracellular mechanisms, analysis
Establishing the Function of TMEM184B in mTORC1 Regulation and Synaptic Maintenance
Active·2023·$82.6K / $434.6K·
External
Co-Investigator (COI)
mtorc1 regulation, tmem184b function, synaptic maintenance, cellular signaling, protein function
ATP Binding Cassette (ABC) Transporters in Fungal Drug Tolerance
Active·2021·$1.5M·
External
Principal Investigator (PI)
fungal drug tolerance, atp binding cassette transporters, fungal infections, drug resistance mechanisms, antifungal therapy
Co-Crystallization of CD8ab with Targeting Antibodies
2021·$15.5K / $30.9K·
External
Principal Investigator (PI)
protein crystallization, immunotherapy, drug development, antigen-antibody interaction, immune system
Co-Crystallization of CD8ab with Targeting Antibodies
2021·$7.7K / $15.5K·
External
Principal Investigator (PI)
protein crystallization, immunotherapy, drug development, antigen-antibody interaction, immune system

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Publications(38)

Recent

Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter

2024

cryo-em, phosphorylation, abc transporter

Structural Basis for Oxidized Glutathione Recognition by the Yeast Cadmium Factor 1

2024

protein interactions, molecular recognition, yeast biology, oxidative stress response

The N-terminal signature motif on the transporter MCT1 is critical for CD147-mediated trafficking

2024

protein transport, cell biology, protein interaction, membrane protein, cellular trafficking

Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation

2024

cryo-em structure, protein transport regulation, phosphorylation, r-domain interaction, ycf1 protein

Structural Basis for Autoinhibition by the Dephosphorylated Regulatory Domain of Ycf1

2023

molecular biology, enzyme regulation, protein structure, cellular transport, biochemistry

Asymmetric intermediates in the transport cycle of ABC transporters

2022

abc transporters, transport cycle, asymmetric intermediates, membrane transport, protein dynamics

Vaccines to prevent coccidioidomycosis: a gene-deletion mutant of Coccidioides posadasii as a viable candidate for human trials

2022

vaccines, coccidioidomycosis, coccidioides posadasii

Biochemical and structural insight of regulation in yeast vacuolar ABC transporter Ycf1

2022

biochemical regulation, structural analysis, yeast transporter, vacuolar transport, abc transporter

The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation

2022

protein regulation, transporter regulation, phosphorylation, cellular transport, structural biology

Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter

2022

drug binding, abc transporter, atp-loaded state, inward-facing, asymmetric binding