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Profile
Shirin Doroudgar
Assistant Professor | Member of the Graduate Faculty
College of Medicine - Phoenix
Full Page
Overview
Research
More
Collaboration
(4)
Shenfeng Qiu
Mutual work: 2 Proposals
Collaboration Details
Tobias Jakobi
Mutual work: 8 Proposals﹒2 Grants
Collaboration Details
Chris Glembotski
Mutual work: 2 Grants﹒5 Proposals
Collaboration Details
Cecily Haskell
Mutual work: 1 Grant﹒1 Supervisor﹒2 Proposals
Collaboration Details
Grants
(2)
Post-Transcriptional Regulation of Gene Expression by Ribosome-Binding Protein 1
Active
·
2024
·
$565.9K / $754.5K
·
External
Principal Investigator (PI)
gene expression regulation,
ribosome-binding protein,
post-transcriptional regulation
(NIA) The RNA Secretome of the Heart
Active
·
2023
·
$0 / $150K
·
External
Key Personnel (KP)
rna,
heart,
secretome,
nia,
research
Publications
(47)
Recent
Development of a protein synthesis network at the sarco/endoplasmic reticulum in adult cardiac myocytes
2024
protein synthesis,
cardiac myocytes,
endoplasmic reticulum,
sarco/endoplasmic reticulum
ATF6 protects against protein misfolding during cardiac hypertrophy
2024
cardiac hypertrophy,
protein misfolding,
atf6,
cardiac function,
cellular stress response
Proteostasis in cardiac health and disease
2024
proteostasis,
cardiac health,
disease,
protein homeostasis,
cardiovascular physiology
Signaling and Stress Response: mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes
2023
stress response,
mtorc1 inhibition,
unfolded protein response,
cell death,
cardiomyocytes
Resolving Proteotoxicity: Genetic Examination of Proteasome Activation by PKA In Vivo
2023
proteasome activation,
genetic examination,
proteotoxicity,
pka,
in vivo
IRE1/XBP1 and endoplasmic reticulum signaling—from basic to translational research for cardiovascular disease
2022
endoplasmic reticulum,
cardiovascular disease,
ire1/xbp1,
translational research,
signaling
Krüppel-like factor 15 expression dynamics with CRISPR-based gene activation controls cardiomyocyte remodeling in the failing heart
2022
gene expression,
cardiomyocyte remodeling,
crispr-based gene activation,
heart failure,
krüppel-like factor 15
Transcriptional Effects of Candidate COVID-19 Treatments on Cardiac Myocytes
2022
covid-19,
cardiac,
transcriptional,
treatment,
myocytes
VARS2 depletion leads to activation of the integrated stress response and disruptions in mitochondrial fatty acid oxidation
2022
mitochondrial function,
cellular stress response,
fatty acid metabolism,
genetic depletion,
metabolic pathways
Age-related decline of the unfolded protein response in the heart promotes protein misfolding and cardiac pathology
2021
aging,
protein misfolding,
cardiac pathology,
heart,
unfolded protein response
