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Marielle Hegetschweiler
Assistant Professor, Chemistry and Biochemistry-Sci | Member of the Graduate Faculty
Chemistry & Biochemistry - Sci
Full Page
Overview
Research
More
Grants
(1)
Towards the Understanding of How Chaperones Function and Prevent Amyloidogenic Diseases
Active
·
2023
·
$498K
·
External
Principal Investigator (PI)
protein folding,
chaperones,
amyloidogenesis,
disease prevention,
molecular biology
Publications
(29)
Recent
Elucidation of a nutlin-derivative—HDM2 complex structure at the interaction site by NMR molecular replacement: A straightforward derivation
2022
structural biology,
drug development,
protein interaction,
nmr spectroscopy,
molecular replacement
Defluorination Capability of l‐2‐Haloacid Dehalogenases in the HAD‐Like Hydrolase Superfamily Correlates with Active Site Compactness
2022
enzyme engineering,
bioremediation,
enzyme catalysis,
protein structure,
biophysical chemistry
Amyloid-β Can Form Fractal Antenna-Like Networks Responsive to Electromagnetic Beating and Wireless Signaling
2022
neuroscience,
biophysics,
electromagnetic fields,
wireless communication,
biology
An Efficient Method of Expression and Purification of Amyloid-Beta Aβ1–42) Peptide from E. coli
2022
protein expression,
protein purification,
amyloid beta,
e. coli,
peptide purification
Visualization of sparsely-populated lower-order oligomeric states of human mitochondrial Hsp60 by cryo-electron microscopy
2021
protein structure,
mitochondrial biology,
cryo-electron microscopy,
chaperone proteins,
biological visualization
Probing the Interaction of Huntingtin Exon‐1 Polypeptides with the Chaperonin Nanomachine GroEL
2021
protein-protein interaction,
chaperonin machinery,
huntingtin protein,
neurodegenerative diseases,
molecular chaperones
A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins
2021
neuropathy,
protein binding,
hsp27 variant,
charcot-marie-tooth,
interface
The three-dimensional structure of human β-endorphin amyloid fibrils
2020
protein structure,
amyloid fibrils,
human physiology,
peptide aggregation,
neuroscience
Rational Structure‐Based Design of Fluorescent Probes for Amyloid Folds
2019
amyloid folds,
fluorescent probes,
structure-based design,
rational design,
fluorescent imaging
Dysregulated interactions triggered by a neuropathy-causing mutation in the IPV motif of HSP27
2019
neuropathy,
mutation,
hsp27,
interactions,
dysregulated