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Picture of Michael Kuhns

Michael Kuhns

Professor, Immunobiology | Senior Scientific Advisor, Center for Advanced Molecular & Immuno Therapies | Professor, Genetics - GIDP | Professor, BIO5 Institute | Professor, Cancer Biology - GIDP | Member of the Graduate Faculty

Collaboration(22)

Janko Nikolich
Karen Hastings
Anne Cress
Paul Langlais
John Galgiani

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Grants(16)

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Publications(26)

Recent

The CD4 transmembrane GGXXG and juxtamembrane C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

2023

cell signaling, cd4 receptor, immune system, transmembrane signaling, protein motifs

The TCR Cα Domain Regulates Responses to Self-pMHC Class II

2022

immunology, t-cell receptor, autoimmunity, peptide-mhc interaction, regulatory t cells

Enhancing and inhibitory motifs regulate CD4 activity

2022

immunology, protein regulation, cell signaling, molecular biology, biochemistry

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

2018

t-cell receptor, cd4 engagement, pmhcii stabilization, receptor macrocomplex, nucleating interaction

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice

2018

ageing, immunology, t-cell, immune response, mouse model

Functional evidence for TCR-intrinsic specificity for MHCII

2016

t-cell receptor, mhc class ii, immunology, cell biology, protein interactions

Author response: Domain-swapped T cell receptors improve the safety of TCR gene therapy

2016

t cell receptors, tcr gene therapy, domain-swapped, safety, gene therapy

The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex

2016

tcr-cd3-pmhc-cd4, cytosolic juxtamembrane, cd4, cd3δε, pmhc

Affinity for self drives the preferential accumulation of promiscuous CD4+ T cells over the lifespan. LYM2P.726)

2015

t cell development, immune system, aging, immune tolerance, autoimmunity

Self-recognition drives the preferential accumulation of promiscuous CD4( T-cells in aged mice

2015

immunology, aging, cell biology, immunosenescence, t cell repertoire