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Picture of Konrad Zinsmaier

Konrad Zinsmaier

Professor, Neuroscience - GIDP | Professor, Neuroscience | Professor, Entomology / Insect Science - GIDP | Professor, Physiological Sciences - GIDP | Professor, Molecular and Cellular Biology | Department Head, Neuroscience | Member of the Graduate Faculty

Collaboration(8)

Cynthia Thomson
Scott Saleska
Andrew Carnie
Carol Barnes
Lucy Ziurys

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Grants(9)

Cysteine-String Protein and Neurodegeneration
Active·2020·$422.1K·
External
Principal Investigator (PI)
neurodegeneration, protein, cysteine, genetics, neuroscience
A Fly Model of Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis (ANCL)
2015·$370.7K·
External
Principal Investigator (PI)
neurodegenerative diseases, genetic models, neuronal ceroid lipofuscinosis, adult-onset diseases, genetics
2015 Bisgrove Scholar Program
2015·$0 / $200K·
External
Co-Investigator (COI)
scholarship, education, biomedical research, funding, career development
Roles of the CSPalpha Chaperone Complex in Presynaptic Maintenance and ANCL
2014·$88.7K·
External
Principal Investigator (PI)
presynaptic maintenance, cspalpha chaperone complex, ancl, roles, chaperone
Role of Miro Signaling for Axonal Transport of Mitochondria
2011·$1.3M·
External
Principal Investigator (PI)
neuroscience, cell biology, mitochondrial dynamics, signal transduction, neurodegenerative diseases

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Publications(39)

Recent

Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation

2022

protein misfolding, neurodegenerative diseases, chaperone proteins, lipofuscin accumulation, genetic mutations

Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics.

2020

mitochondrial dynamics, peroxisomal dynamics, miro gtpases, mitochondrial coordination, cellular dynamics

A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism.

2019

neuronal ceroid lipofuscinosis, drosophila model, gain of function mechanism, hypermorphic, cln4

Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity.

2019

neurotransmitter release, plasticity, ubiquitin ligase, dcaf12, homeostasis

High fidelity cryopreservation and recovery of rodent cortical neurons

2018

cryopreservation, neuron recovery, rodent neurons, high fidelity preservation, cortical neurons

Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS

2017

als, synaptic vesicles, hsc70-4, post-transcriptional inhibition, hspa8 expression

Mitochondria on the Road to Power Axonal Regeneration

2016

mitochondria, axon regeneration, cellular energy, neurological regeneration, cellular transport

Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites

2015

mitochondrial transport, gtpase domain, axonal transport, dendritic transport, mitochondrial dynamics

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

2015

membrane potential, phospholipid dynamics, k-ras signaling, plasma membrane, cell signaling

PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila

2014

neuroscience, genetics, cell biology, neurodegenerative diseases, synaptic plasticity