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Picture of Jacob Schwartz

Jacob Schwartz

Associate Professor, Neuroscience - GIDP | Associate Professor, BIO5 Institute | Assistant Professor, Chemistry and Biochemistry - Med | Associate Research Professor, Pharmacology - (Research Series Track) | Member of the Graduate Faculty | Associate Professor, Cancer Biology - GIDP

Collaboration(8)

Todd Vanderah
Paul Langlais
Frank Porreca
John Ruiz
Koenraad Van Doorslaer

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Grants(10)

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Publications(13)

Recent

Binding of the nuclear ribonucleoprotein family member FUS to RNA prevents R-looRNA:DNA hybrid structures

2023

rna binding, dna-rna interaction, nuclear ribonucleoproteins, r-loop formation, fus protein

Fusion protein EWS-FLI1 is incorporated into a protein granule in cells

2021

protein regulation, cell biology, gene fusion, protein aggregation, oncology

Isolating and Analyzing Protein Containing Granules from Cells

2021

proteomics, cell biology, biochemistry, cellular imaging, cell fractionation

Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

2021

traumatic injury, nucleocytoplasmic transport, tdp-43 pathology, brain trauma, neurodegeneration

Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage

2020

protein-protein interactions, dna damage, neurodegeneration, gene regulation, cellular stress response

Discriminating changes in protein structure using tyrosine conjugation

2020

protein structure, chemical modifications, conjugation analysis, protein characterization, biological assays

Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation

2019

hiv latency, gene transcription, viral latency, sarcoma research, gene silencing

TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons

2019

transcription regulation, protein-coding genes, tdp-43, alu retrotransposons, gene regulation

Transcription-Dependent Formation of Nuclear Granules Containing FUS and RNA Pol II

2018

transcription regulation, rna processing, nuclear organization, protein aggregation, gene expression

Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding

2017

protein interaction, rna binding, intrinsically disordered proteins, degenerate specificity, rgg/rg domains