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Picture of Haining Zhu

Haining Zhu

Professor, Chemistry and Biochemistry-Sci | Professor, Neuroscience - GIDP | Professor, Pharmacology and Toxicology | Endowed Chair, R Ken and Donna Coit - Aging and Neurodegenerative Diseases | Professor, Innovations in Aging - GIDP | Member of the Graduate Faculty

Pharmacology and Toxicology

Collaboration(15)

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Grants(8)

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Publications(123)

Recent

Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

2024

cancer, drug resistance, cell cycle, prostate, phosphorylation

m6A-mediated epi-transcriptomic dysregulation underlies synaptic dysfunction in fragile X syndrome

2024

epitranscriptomics, fragile x syndrome, epigenetics

Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids

2024

blood-brain barrier, modeling

Stress Granules Play a Critical Role in Hexavalent Chromium-Induced Malignancy in a G3BP1 Dependent Manner

2024

malignancy, g3bp1

An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m6A-mediated epi-transcriptomic dysregulation underlying synaptic dysfunction

2024

synaptic dysfunction, fragile x syndrome, clinical phenotypes

Interference of nuclear speckles: A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD

2024

rna regulation, neurodegenerative diseases

Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis

2024

rna regulation, cancer biology, gene expression regulation, lung cancer, molecular interaction

ABL1/2 and DDR1 drive MEKi resistance in NRAS-mutant melanomas by stabilizing RAF/MYC/ETS1 and promoting RAF homodimerization

2023

melanomas, drug resistance, cell signaling, kinases, cancer treatment

Mid‐life APOE4 to APOE2 ‘Switching’Alters the Cerebral Transcriptome and Lipidome in a Transgenic Mouse Model

2023

genetics, neuroscience, transcriptomics, lipidomics, aging

Yin and yang regulation of stress granules by Caprin-1

2022

stress granules, yin and yang regulation, caprin-1, regulation, cellular stress response