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Picture of Felicia Goodrum

Felicia Goodrum

Professor, Cellular and Molecular Medicine | Member of the Graduate Faculty | Professor, Molecular and Cellular Biology | Professor, BIO5 Institute | Interim Associate Department Head, Immunobiology | Professor, Immunobiology | Professor, Cancer Biology - GIDP | Professor, Genetics - GIDP

Collaboration(26)

Mindy Fain
Sairam Parthasarathy
Kenneth Knox
Melissa Herbst-Kralovetz
Bonnie LaFleur

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Labs(1)

GoodRum Lab
Many viruses asymptomatically co-exist within the human host. Understanding the mechanisms by which these viruses persist—in the absence of overt disease—is the major focus of our lab. These stealthy viruses are also powerful tools for probing and understanding cell biology important to signaling, immune evasion, cell survival, and differentiation. Human cytomegalovirus (CMV) is a beta-herpesviruses that persists in the majority of the world’s population by establishing a latent infection. Latency is defined as a reversibly quiescent state during which viral gene expression and replication is highly restricted. We use CMV as a model for defining and understanding the interactions between viruses and their hosts that allow for the entry into and exit from latent states. Understanding latency and viral persistence is critical to developing novel antiviral therapies to control persistence and its consequences in at-risk individuals, such as stem cell and organ transplant recipients.

Grants(29)

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Publications(73)

Recent

Viral and host network analysis of the human cytomegalovirus transcriptome in latency

2024

latency, human cytomegalovirus

Virology – the next fifty years

2024

virology, infectious diseases, epidemiology, vaccine development, public health

Virology-the path forward

2024

virology, infectious diseases, epidemiology, vaccine development, public health

The harms of promoting the lab leak hypothesis without evidence

2024

public health, misinformation, ethics, media influence

Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins

2023

viral infection, host-pathogen interaction, cell signaling, protein destabilization, virus-host interaction

Field Research Is Essential to Counter Virological Threats

2023

virology, field research, viral threats, public health, epidemiology

A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses

2023

virus origin, epidemiology, microbiology, public health, genomics

Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection

2023

viral infection, cell biology, host-pathogen interaction, gene regulation, immunology

Virology under the Microscope-a Call for Rational Discourse

2023

virology, public health, scientific communication, microbiology, epidemiology

Liver X Receptor-Inducible Host E3 Ligase IDOL Targets a Human Cytomegalovirus Reactivation Determinant

2023

viral reactivation, host-pathogen interactions, immune response, protein degradation, gene regulation