Profile

Darren Cusanovich

Member of the Graduate Faculty | Assistant Professor, BIO5 Institute | Assistant Professor, Cellular and Molecular Medicine

Cellular & Molecular Medicine

Full Page

Overview

Research

Collaboration(49)

Page 1 of 10

Grants(11)

Defining Mechanisms Of Cc16 On Epithelial-driven Host Responses To Pathogens
Active·2024·$30.3K / $606.4K·
External
Co-Investigator (COI)
lung inflammation, host-pathogen interaction, epithelial cells, immune response, biomarker
Exploring How Genetic Variation Influences Endothelial Plasticity in Response to Fluid Shear Stress
Active·2024·$0 / $67.4K·
External
Key Personnel (KP)
genetic variation, endothelial plasticity, fluid shear stress, response, exploring
PARP1 and PARylation as Novel Effectors of Gut Inflammation
Active·2023·$24.3K / $1.3M·
External
Co-Investigator (COI)
inflammation, parp1, gut, parylation, effectors
Transcriptional Regulation of Antibody Responses and Immunity
Active·2023·$0 / $1.1M·
External
Key Personnel (KP)
transcriptional regulation, antibody response, immunity, transcription, regulation
Glyoxalase 1 and its Role in Metabolic Syndrome
Active·2023·$172.6K / $863.1K·
External
Co-Investigator (COI)
metabolic syndrome, glyoxalase 1, role, metabolism, enzyme

Page 1 of 3

Publications(112)

Recent

Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors.

2024

virology, antibodies, drug discovery, cell biology, biomedical research

txci-ATAC-seq: a massive-scale single-cell technique to profile chromatin accessibility

2024

single-cell, chromatin accessibility, atac-seq, technique

Ultrasound-guided nerve blocks in emergency medicine practice: 2022 updates

2024

ultrasound-guided nerve blocks, emergency medicine, medical ultrasound, pain management, emergency care procedures

Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation

2024

inflammation, macrophages, histone modification, signal transduction, glutathione

txci-ATAC-seq, a massive-scale single-cell technique to profile chromatin accessibility

2023

single-cell, chromatin accessibility, atac-seq, massive scale, profiling

CC16 Induces Pulmonary Epithelial-Driven SPLUNC1 Expression by Signaling through VLA-2.

2023

lung immunology, pulmonary epithelial cells, cc16 protein, splunc1 expression, cell signaling

Single cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveals heterogeneity of endothelial subtype and response to activating perturbations

2023

endothelial cells, atherosclerosis, single-cell analysis, heterogeneity, activating perturbations

Ten 10) X-compatible Combinatorial Indexing ATAC sequencing txci-ATAC-seq)

2023

atac sequencing, combinatorial indexing, x-compatible, txci-atac-seq, research methods

CC16 drives VLA-2-dependent SPLUNC1 expression

2023

cc16, vla-2, splunc1, expression, immune response

Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation

2023

cell biology, pediatrics, immune system, respiratory system, developmental biology

People

Profile

Darren Cusanovich

Collaboration(49)

Bonnie LaFleur

Fernando Martinez

David Besselsen

Megha Padi

Dean Billheimer

Grants(11)

Defining Mechanisms Of Cc16 On Epithelial-driven Host Responses To Pathogens

Exploring How Genetic Variation Influences Endothelial Plasticity in Response to Fluid Shear Stress

PARP1 and PARylation as Novel Effectors of Gut Inflammation

Transcriptional Regulation of Antibody Responses and Immunity

Glyoxalase 1 and its Role in Metabolic Syndrome

Publications(112)

Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors.

txci-ATAC-seq: a massive-scale single-cell technique to profile chromatin accessibility

Ultrasound-guided nerve blocks in emergency medicine practice: 2022 updates

Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation

txci-ATAC-seq, a massive-scale single-cell technique to profile chromatin accessibility

CC16 Induces Pulmonary Epithelial-Driven SPLUNC1 Expression by Signaling through VLA-2.

Single cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveals heterogeneity of endothelial subtype and response to activating perturbations

Ten 10) X-compatible Combinatorial Indexing ATAC sequencing txci-ATAC-seq)

CC16 drives VLA-2-dependent SPLUNC1 expression

Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation