AbstractOral and oropharyngeal squamous cell carcinoma (OSCC) together rank as the sixth most common cancerworldwide accounting for approximately 400000 new cases each year. The 5-year survival rate in the U.S. forOSCC is 62% the survival rate is only 10-40% and the cure rate around 30% in the developing world. Lowsurvival rate is primarily attributed to the delay in diagnosis and the resultant progression of disease to anadvanced stage at diagnosis. Early diagnosis offers the best chance to improved treatment outcomes andsurvival for an individual diagnosed with OSCC.The objective of this proposed project focuses on developing and evaluating a low-cost compact smartphonecompatible multimodal intraoral confocal probe for noninvasive in situ detection of oral dysplasia and early stagecancer. The key innovation of the proposed intraoral confocal probe is low-cost and compact confocal intraoralprobe using actively addressable point source array - microLED (LED) without any moving parts to achieve 3Dconfocal imaging. The wide-FOV autofluorescence imaging (AFI) and polarized white light imaging (pWLI) willidentify the suspicious regions with the help of trained neural network and guide confocal scan to obtain tissuemicrostructure for accurate diagnosis. We will achieve this objective through the following two Aims: (1) developmultimodal confocal imaging probe with LED array and (2) evaluate the performance and clinical feasibility ofmultimodal intraoral probe.The proposed project has a great significance. The compact multimodal handheld intraoral imaging probe inconjunction with the deep learning image classification method will enable noninvasive in situ early detectionand diagnosis of oral dysplasia and cancer from benign conditions in a clinical setting significantly reducingdisease progression reducing death rates from oral cancer and improving the quality of life. The cost-effectivesmartphone compatible design is extremely suitable for screening oral cancer through remote diagnosis in low-resource setting significantly improve the survive rate of oral cancers in low- and middle- income countries.