Abstract. The purpose of this project is to create a novel, comprehensive Interprofessional Collaborative Practice (IPCP) primary care environment (Health 360) that will achieve three central goals: 1) Coordinated, connected, comprehensive care for patients and families with actual or risk of chronic disease/illness through nurse practitioner (NP) leadership and shared leadership of interprofessional (IP) teams; 2) Clinical training opportunities for nursing students and other health professional students designed to master IP collaborative practice core competencies; and 3) Innovative community engagement IP collaborative practice for disease prevention and health promotion. Specifically, the College of Nursing will establish the Health 360 practice environment in collaboration with the Department of Family and Community Medicine at the University of Arizona Medical Center South campus (UAMCS), which has a 245 bed hospital, a state-of-the-art new Behavioral Health Pavilion and Crisis Response Center, and a completely remodeled building to house several primary and specialty care clinics. This entity is aligned within The University of Arizona Health Network (UAHN), along with UAMC—the University Campus hospital, clinics and centers, and citywide clinics. On the University Campus, the Colleges of Nursing, Medicine, Pharmacy and Public Health are housed, which with the UAHN comprise the Arizona Health Sciences Center (AHSC). The Health 360 model will deliver team based care utilizing the tenets of practice stratification and proactive panel management. The core health team for a patient unit (patient and supportive others) will be a primary care Nurse Practitioner or Physician (Family and Community Medicine or Internal Medicine) lead, RN Patient Advocate for patients who are socioeconomically challenged or health literacy challenged, and a community health worker (or promotora). Innovations include bundling of primary care “plus” services with features of 1) comprehensive assessment; 2) rapid stabilization of chronic conditions (rescue) as needed; 3) long-term in individualized health planning and follow-up; 4) individual “plus” visits (i.e. focus group appointments with other patients with similar conditions to allow for health education and peer support and individual check time with appropriate IP team health professionals; 5) continuous connectedness (communications) through a patient portal for documentation and consultation; 6) transitional care if hospitalized; 7) home visits and/or telehealth monitoring; 8) pharmacology audits and medication therapy management; and 9) specialty referrals. The Health 360 practice environment (Goal 2) will support novel opportunities for students from nursing, medicine, pharmacy and/or public health to have experiential learning with IP dialogue and analysis. Innovations include: 1) exposure in peer dialogue to IP core competencies and team building science, 2) participation in bundled care dimensions with emphasis on cross- functional team performance, and 3) community-based participatory leadership for disease prevention/health promotion. For Goal 3, the Health 360 team will partner with the Prevention and Health Promotion Centers of the Mel and Enid Zuckerman College of Public Health in service-learning approaches and community-based interventions with south Tucson’s high health disparity populations. A statutory funding preference is requested because this project substantially benefits underserved (and rural) populations.